Cancer treatment represents one of the main scientific study targets today, mainly due to the pronounced side effects arising from chemotherapy. This study reports the synthesis, characterization, and anticancer activity of ten compounds from the Morita-Baylis-Hillman reaction. Ethylene glycol diacrylate was used as a double Michael acceptor in reactions with isatin derivatives to give homodimers of 3-hydroxyindolin-2-one core, recognized in the literature for its extensive pharmacological profile. The use of 1,4-diazabicyclo[2,2,2]octane (DABCO) as a catalyst and room temperature were the optimal conditions for the study reaction. The isolated yields were up to 63%, with most reaction times inferior to 24 h, some as fast as 15 min. The anticancer potential of the synthesized dimers was evaluated in vitro against three cancer strains, resulting in average inhibitory concentrations up to 0.72 µM. It was also found that the best performing homodimers are more active than their monomeric counterparts. Considering the promising selectivity indices observed, the preliminary results obtained here act as a basis for broader tests regarding the effectiveness of homodimeric adducts against cancer cells.

Avaliar a resistência de união ao cisalhamento de reparos de resina composta com e sem envelhecimento da superfície a ser reparada, utilizando diferentes sistemas adesivos. Noventa corpos de prova foram confeccionados sendo: 10 para o Grupo Controle (GC - sem reparo); 40 para o Grupo I (GI - reparos após 7 dias) e 40 para o Grupo II (GII - reparos após 180 dias). Para os reparos, os grupos GI e GII foram subdivididos em 4 subgrupos com 10 corpos de prova, variando o sistema adesivo e a resina composta: A) Adper Scotch Bond Multipurpose+ Filtek Z350XT; B)Adper Single Bond Plus+ Filtek Z350XT; C)Adper Scotch Bond Multipurpose+ Esthet-X; D) Adper Single Bond Plus+ Esthet-X. Os corpos de prova foram submetidos a uma força de cisalhamento em uma máquina de ensaio universal (EMIC). Os resultados foram analisados pelo teste estatístico Anova dois fatores, seguido pelo teste de Fisher´s. Observou-se melhor comportamento do grupo controle sobre os demais grupos, além disso, os reparos realizados aos 7 dias foram superiores aos dos realizados em 180 dias. Não houve diferença significativaquando se comparou diferentes sistemas adesivos e resinas compostas. Os reparos de resina composta diminuem a resistência mecânica da restauração.O envelheci mento do substrato de resina pode diminuir a resistência ao reparo ao longo do tempo, independentemente do tipo de sistemas adesivos e resinas compostas utilizados.

The aim of this study was to evaluate the shear bond strength of resin composite repairs with and without aging of the surface to be repaired, using different adhesive systems and resin composites. Ninety specimens were prepared: 10 for the Control Group (GC - without repair); 40 for Group I (GI - repairs after 7 days) and 40 for Group II (GII - repairs after 180 days). Groups I and II were divided into 4 subgroups of 10 specimens each, according to the adhesive system and composite resin used: A) Adper Scotch Bond Multipurpose + Filtek Z350 XT; B) Adper Single Bond Plus + Filtek Z350 XT; C) Adper Scotch Bond Multipurpose + Esthet-X; D) Adper Single Bond Plus + Esthet-X. The specimens were tested for shear strength in a universal testing machine. The results were analyzed by two-factor one-way ANOVA and Fisher's post hoc tests (alpha=0.05). The control group had better performance than the other groups. There was no significant difference when comparing different adhesive systems and composite resins. Repairs performed at 7 days were better than those performed at 180 days. The composite repairs decreased the mechanical strength of the restoration. Aging of the resin substrate may decrease repair bond strength over time, regardless of the type of adhesive systems and resin composites used.

Objetivos: O objetivo deste estudo foi avaliar utilizando um sistema adesivo de 2 passos de condicionamento ácido total, a correlação entre a espessura da camada híbrida (CH) e a resistência de união (RU), e entre o comprimento dos tags resinosos (TR) e a RU em um mesmo dente utilizando, assim como o padrão de fratura dos espécimes testados. Material e método: Dez molares humanos foram utilizados para o procedimento restaurador e seccionados em duas metades (mésio-distal). Os materiais utilizados foram Adper ™ Single Bond 2, 3M ESPE, gel Ultra ™ etch, Ultradent e Filtek Z250, 3M ESPE.Uma metade foi utilizada para a microscopia de luz (400x) para se obter a espessura da CH e o comprimento dos TR, e a outra metade foi submetida ao teste de microtração para obtenção da RU. As superfícies fraturadas foram analisadas por microscopia eletrônica de varredura e os padrões de fratura classificados. O teste de correlação de Pearson foi aplicado p=0.05. Resultados: Os resultados das análises de cada espécime (CH, TR e RU), em seguida, foram correlacionados: CH espessura média = 4,39(0,48) μm, comprimento médio dos TR = 9,94(1,69) μm, média da RU= 23,98(10,24) MPa. Correlação estatisticamente significativa foi encontrada entre a espessura da CH e RU (r=0,93). Conclusão: o sistema adesivo de condicionamento ácido total de dois passos mostrou forte correlação entre a espessura da camada híbrida e resistência de união. Os tipos de fraturas mais comuns foram a adesiva, seguida da coesiva na resina.

The objective of this study was to evaluate the use of a two-step total etch and rinse adhesive, the correlation between the hybrid layer thickness (HL) and bond strength (BS), and between resin tag length (RT) and bond strength in the same teeth, and also to evaluate the fracture patterns of the tested specimens. Ten human molars were used for the restorative procedure and then sectioned in two halves (mesio-distally). The materials used were Adper™ Single Bond 2, 3M ESPE, Ultra etch gel, Ultradent and Filtek™ Z250, 3M ESPE. One half were utilized to measure the HL thickness and RT length through light microscopy analysis (400x), and the other half was subject to a microtensile test to measure the BS. The fractured surfaces were analyzed by scanning electron microscopy and fracture patterns classified. The Pearson correlation test was applied (p=0.05). The results of the analyses of each specimen then were correlated: mean HL thickness = 4.39(0.48) μm, mean length of RT = 9.94(1.69) μm, mean BS = 23.98(10.24) MPa. A statistically significant correlation between HL thickness and bond strength was found (r=0.93). The two step etch and rinse adhesive system, showed a strong correlation between HL thickness and bond strength. The most common fractures were adhesive, followed by cohesive in resin.